Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lgr5  leucine rich repeat containing G protein coupled receptor 5   (Synonyms: Gpr49)
Results	Reference
1	J:177655 Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K, Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29
1	J:262507 Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H, Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep. 2012 Sep 27;2(3):540-52
1*	J:127123 Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H, Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007 Oct 25;449(7165):1003-7
1	J:173579 Chai R, Xia A, Wang T, Jan TA, Hayashi T, Bermingham-McDonogh O, Cheng AG, Dynamic expression of lgr5, a wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol. 2011 Aug;12(4):455-69
1*	J:277739 Chaves-Perez A, Yilmaz M, Perna C, de la Rosa S, Djouder N, URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019 May 31;364(6443)
1*	J:311215 Fazilaty H, Brugger MD, Valenta T, Szczerba BM, Berkova L, Doumpas N, Hausmann G, Scharl M, Basler K, Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage. Cell Rep. 2021 Aug 3;36(5):109484
1	J:221041 Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR, Abud HE, Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J. 2015 May 12;34(10):1319-35
1*	J:143598 Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgard R, Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008 Nov;40(11):1291-9
1	J:289321 Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K, Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach. Int J Mol Sci. 2019 Jun 17;20(12):2955
1	J:252705 Kriz V, Krausova M, Buresova P, Dobes J, Hrckulak D, Babosova O, Svec J, Korinek V, Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse. Transgenic Res. 2017 Oct;26(5):689-701
1	J:219387 Ng A, Tan S, Singh G, Rizk P, Swathi Y, Tan TZ, Huang RY, Leushacke M, Barker N, Lgr5 marks stem/progenitor cells in ovary and tubal epithelia. Nat Cell Biol. 2014 Aug;16(8):745-57
1	J:240625 Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S, Soshnikova N, Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J. 2017 Apr 03;36(7):869-885
1	J:328944 Olbertova K, Hrckulak D, Kriz V, Jesionek W, Kubovciak J, Esner M, Korinek V, Buchtova M, Role of LGR5-positive mesenchymal cells in craniofacial development. Front Cell Dev Biol. 2022;10:810527
1*	J:202041 Page ME, Lombard P, Ng F, Gottgens B, Jensen KB, The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell. 2013 Oct 3;13(4):471-82
1	J:216158 Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D, Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
1*	J:334516 Reichmuth J, vom Berg J, Brugger M, Hausmann G, Valenta T, Basler K, Manipulating the murine Lgr5 locus using a rapid, efficient and flexible CRISPR/Cas9 pipeline. bioRxiv. 2020;
1	J:327384 Ren W, Ma Z, Wang L, Feng X, Yu H, Yu Y, Lgr5(+) cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages. Theranostics. 2022;12(13):5631-5644
1	J:340421 Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, Wei R, Morel MM, Koch A, Forman M, Reeve G, Lecholop MK, Wilson M, Bonthius D, Chen M, Ono M, Wang TC, Yao H, Embree MC, Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023 Sep 7;30(9):1179-1198.e7
1	J:260403 Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F, Plasticity within the niche ensures the maintenance of a Sox2(+) stem cell population in the mouse incisor. Development. 2018 Jan 8;145(1):dev155929
1*	J:268713 Schweiger PJ, Clement DL, Page ME, Schepeler T, Zou X, Sirokmany G, Watt FM, Jensen KB, Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro. Sci Rep. 2018 Oct 15;8(1):15255
1*	J:157895 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
1*	J:343157 Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H, Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 2009 Jun;136(7):2187-2194.e1
1	J:236406 Takada Y, Fukuda A, Chiba T, Seno H, Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development. 2016 Oct 1;143(19):3532-3539
1	J:195123 Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA, Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development. 2013 Apr;140(8):1655-64
1	J:309439 Tang Y, Yang G, Zhang J, Li X, Zhang C, Wang Y, Xu J, Chen Y, Teng Y, Yang X, E-cadherin is Required for the Homeostasis of Lgr5(+) Gastric Antral Stem Cells. Int J Biol Sci. 2019;15(1):34-43
1	J:305498 Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W, LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death Dis. 2020 Jul 27;11(7):588
1	J:295894 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D, Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development. 2020 Sep 2;147(17):dev185678
1	J:338913 Xiang J, Guo J, Zhang S, Wu H, Chen YG, Wang J, Li B, Liu H, A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche. BMC Biol. 2023 Aug 8;21(1):169
1	J:273440 Zak M, van Oort T, Hendriksen FG, Garcia MI, Vassart G, Grolman W, LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186